Signal Peptide Website
Search my Protein
Advanced Search
Database Search
References
Hints
Links
Imprint
Signal Peptide Database - Viruses
Entry Details
ID
4291
Source Database
UniProtKB/Swiss-Prot
UniProtKB/Swiss-Prot Accession Number
P15831 (Created: 1990-04-01 Updated: 2008-11-25)
UniProtKB/Swiss-Prot Entry Name
ENV_HV2D2
Protein Name
Envelope glycoprotein gp160
Gene
env
Organism Scientific
Human immunodeficiency virus type 2 (isolate D205 subtype B)
Organism Common
HIV-2
Lineage
Viruses
Retro-transcribing viruses
Retroviridae
Orthoretrovirinae
Lentivirus
Primate lentivirus group
Protein Length [aa]
859
Protein Mass [Da]
98607
Features
Type
Description
Status
Start
End
signal peptide
potential
1
23
chain
Envelope glycoprotein gp160
24
859
chain
Surface protein
by similarity
24
513
chain
Transmembrane protein
by similarity
514
859
disulfide bond
by similarity
44
57
disulfide bond
by similarity
101
214
disulfide bond
by similarity
108
205
disulfide bond
by similarity
113
164
disulfide bond
by similarity
227
257
disulfide bond
by similarity
237
249
disulfide bond
by similarity
305
338
disulfide bond
by similarity
392
449
disulfide bond
by similarity
399
422
transmembrane region
potential
679
699
topological domain
Extracellular
potential
24
678
topological domain
Cytoplasmic
potential
700
859
region of interest
V1
113
163
region of interest
V2
164
205
region of interest
V3
305
337
region of interest
V4
399
422
region of interest
V5
465
471
region of interest
Fusion peptide
potential
514
534
region of interest
Immunosuppression
by similarity
577
593
glycosylation site
N-linked (GlcNAc...)
potential
37
37
glycosylation site
N-linked (GlcNAc...)
potential
70
70
glycosylation site
N-linked (GlcNAc...)
potential
112
112
glycosylation site
N-linked (GlcNAc...)
potential
122
122
glycosylation site
N-linked (GlcNAc...)
potential
142
142
glycosylation site
N-linked (GlcNAc...)
potential
150
150
glycosylation site
N-linked (GlcNAc...)
potential
165
165
glycosylation site
N-linked (GlcNAc...)
potential
191
191
glycosylation site
N-linked (GlcNAc...)
potential
206
206
glycosylation site
N-linked (GlcNAc...)
potential
238
238
glycosylation site
N-linked (GlcNAc...)
potential
241
241
glycosylation site
N-linked (GlcNAc...)
potential
248
248
glycosylation site
N-linked (GlcNAc...)
potential
272
272
glycosylation site
N-linked (GlcNAc...)
potential
278
278
glycosylation site
N-linked (GlcNAc...)
potential
289
289
glycosylation site
N-linked (GlcNAc...)
potential
300
300
glycosylation site
N-linked (GlcNAc...)
potential
310
310
glycosylation site
N-linked (GlcNAc...)
potential
343
343
glycosylation site
N-linked (GlcNAc...)
potential
367
367
glycosylation site
N-linked (GlcNAc...)
potential
400
400
glycosylation site
N-linked (GlcNAc...)
potential
410
410
glycosylation site
N-linked (GlcNAc...)
potential
413
413
glycosylation site
N-linked (GlcNAc...)
potential
450
450
glycosylation site
N-linked (GlcNAc...)
potential
464
464
glycosylation site
N-linked (GlcNAc...)
potential
468
468
glycosylation site
N-linked (GlcNAc...)
potential
613
613
glycosylation site
N-linked (GlcNAc...)
potential
622
622
glycosylation site
N-linked (GlcNAc...)
potential
638
638
site
Cleavage; by host furin
by similarity
513
514
compositionally biased region
Poly-Thr
126
129
compositionally biased region
Poly-Gln
551
555
lipid moiety-binding region
S-palmitoyl cysteine; by host
by similarity
775
775
coiled-coil region
potential
543
593
coiled-coil region
potential
630
664
SP Length
23
----+----1----+----2----+----3----+----4----+----5
Signal Peptide
MAYFSSRLPIALLLIGISGFVCK
Sequence
MAYFSSRLPIALLLIGISGFVCK
QYVTVFYGIPAWR
N
ATVPLICATTNRD
TWGTVQCLPDNGDYTEIRL
N
ITEAFDAWDNTVTQQAVDDVWRLFETSIKP
CVKLTPLCVAM
N
CSKTETNPG
N
ASS
TTTT
KPTTTSRGLKTI
N
ETDPCIK
N
DSCTGLGEEEIMQ
C
N
FSMTGLRRDELKQYKDTWYSEDLEC
N
NTRKYTSRC
YIRTC
N
TTIIQESCDKHYWDSLRFRYCAPPGFFLLRC
N
DT
N
YSGFMP
N
CS
KVVASSCTRMMETQSSTWFGF
N
GTRAE
N
RTYIYWHEKD
N
RTIISLNTYY
N
LSIH
CKRPG
N
KTVVPIRTVSGLLFHSQPINKRPRQAW
CWFKG
N
WTEAIKE
VKRTIIKHPRYKGGAK
N
ITSVKLVSEHGKGSDPETTYMWTNCRGEFLY
C
N
MTWFLNWVE
N
KT
N
TTRRNYAPC
HIRQIINTWHKVGKNIYLPPREGELSC
N
STVTSLIANINSD
N
STT
N
ISV
SAEVSELYRLELGDYKLVEITPIGFAPTD
VRRYSSVKPRNK
RG
VMVLGFLGFLAMAGSAMGAT
SLTLSAQS
RTLLAGIV
QQQQQPVDVVKRQQELLRLTVWGTKNLQARVTAIEKYLKDQAQ
LNSWGCA
FRQVCHTTVPWP
N
ETLTPNWN
N
MTWQQWE
KQVHFLDANITALLEEAQIQQ
EKNMYELQKINSWD
VFGNWFDLTSWIKY
IHLGLYIVAGLVVLRIVVYIV
Q
MLARLRKGYRPVFSSPPSYTQQIPIRKDRGQPANEETEEGGGNDGDYRSW
PWQIEYIHFLLRQLRNLLIWLYNG
C
RTLLLKTFQILHQISTNLQPLRLPV
AYLQYGISWFQEALRAAARATGETLASAGETLWEALRRAARAIIAIPRRI
RQGLELTLL
Original
MAYFSSRLPIALLLIGISGFVCKQYVTVFYGIPAWRNATVPLICATTNRD
TWGTVQCLPDNGDYTEIRLNITEAFDAWDNTVTQQAVDDVWRLFETSIKP
CVKLTPLCVAMNCSKTETNPGNASSTTTTKPTTTSRGLKTINETDPCIKN
DSCTGLGEEEIMQCNFSMTGLRRDELKQYKDTWYSEDLECNNTRKYTSRC
YIRTCNTTIIQESCDKHYWDSLRFRYCAPPGFFLLRCNDTNYSGFMPNCS
KVVASSCTRMMETQSSTWFGFNGTRAENRTYIYWHEKDNRTIISLNTYYN
LSIHCKRPGNKTVVPIRTVSGLLFHSQPINKRPRQAWCWFKGNWTEAIKE
VKRTIIKHPRYKGGAKNITSVKLVSEHGKGSDPETTYMWTNCRGEFLYCN
MTWFLNWVENKTNTTRRNYAPCHIRQIINTWHKVGKNIYLPPREGELSCN
STVTSLIANINSDNSTTNISVSAEVSELYRLELGDYKLVEITPIGFAPTD
VRRYSSVKPRNKRGVMVLGFLGFLAMAGSAMGATSLTLSAQSRTLLAGIV
QQQQQPVDVVKRQQELLRLTVWGTKNLQARVTAIEKYLKDQAQLNSWGCA
FRQVCHTTVPWPNETLTPNWNNMTWQQWEKQVHFLDANITALLEEAQIQQ
EKNMYELQKINSWDVFGNWFDLTSWIKYIHLGLYIVAGLVVLRIVVYIVQ
MLARLRKGYRPVFSSPPSYTQQIPIRKDRGQPANEETEEGGGNDGDYRSW
PWQIEYIHFLLRQLRNLLIWLYNGCRTLLLKTFQILHQISTNLQPLRLPV
AYLQYGISWFQEALRAAARATGETLASAGETLWEALRRAARAIIAIPRRI
RQGLELTLL
----+----1----+----2----+----3----+----4----+----5
Hydropathies
Home
Imprint
© 2007-2017
Dr. Katja Kapp
, Kassel &
thpr.net e. K.
, Dresden, Germany, last update 2010-06-11