Signal Peptide Database

Signal Peptide Database - Viruses

Entry Details

5308

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P05878 (Created: 1988-11-01 Updated: 2008-11-25)

UniProtKB/Swiss-Prot Entry Name

ENV_HV1SC

Protein Name

Envelope glycoprotein gp160

Gene

env

Organism Scientific

Human immunodeficiency virus type 1 (isolate SC group M subtype B)

Organism Common

HIV-1

Lineage

Viruses
  Retro-transcribing viruses
    Retroviridae
      Orthoretrovirinae
        Lentivirus
          Primate lentivirus group

Protein Length [aa]

856

Protein Mass [Da]

97056

Features

TypeDescriptionStatusStartEnd
signal peptide      by similarity   1   31
chain   Envelope glycoprotein gp160      32   856
chain   Surface protein   by similarity   32   510
chain   Transmembrane protein   by similarity   511   856
disulfide bond      by similarity   53   73
disulfide bond      by similarity   118   206
disulfide bond      by similarity   125   197
disulfide bond      by similarity   130   160
disulfide bond      by similarity   219   247
disulfide bond      by similarity   228   239
disulfide bond      by similarity   296   330
disulfide bond      by similarity   376   439
disulfide bond      by similarity   383   412
transmembrane region      potential   685   705
topological domain   Extracellular   potential   30   684
topological domain   Cytoplasmic   potential   706   856
region of interest   V1      130   159
region of interest   V2      160   197
region of interest   V3      296   329
region of interest   V4      383   412
region of interest   V5      455   470
region of interest   Fusion peptide   potential   511   531
region of interest   Immunosuppression   by similarity   576   592
region of interest   Involved in GalCer binding   by similarity   662   667
glycosylation site   N-linked (GlcNAc...)   potential   87   87
glycosylation site   N-linked (GlcNAc...)   potential   129   129
glycosylation site   N-linked (GlcNAc...)   potential   135   135
glycosylation site   N-linked (GlcNAc...)   potential   140   140
glycosylation site   N-linked (GlcNAc...)   potential   143   143
glycosylation site   N-linked (GlcNAc...)   potential   159   159
glycosylation site   N-linked (GlcNAc...)   potential   163   163
glycosylation site   N-linked (GlcNAc...)   potential   189   189
glycosylation site   N-linked (GlcNAc...)   potential   198   198
glycosylation site   N-linked (GlcNAc...)   potential   234   234
glycosylation site   N-linked (GlcNAc...)   potential   241   241
glycosylation site   N-linked (GlcNAc...)   potential   262   262
glycosylation site   N-linked (GlcNAc...)   potential   276   276
glycosylation site   N-linked (GlcNAc...)   potential   295   295
glycosylation site   N-linked (GlcNAc...)   potential   301   301
glycosylation site   N-linked (GlcNAc...)   potential   302   302
glycosylation site   N-linked (GlcNAc...)   potential   331   331
glycosylation site   N-linked (GlcNAc...)   potential   338   338
glycosylation site   N-linked (GlcNAc...)   potential   354   354
glycosylation site   N-linked (GlcNAc...)   potential   360   360
glycosylation site   N-linked (GlcNAc...)   potential   384   384
glycosylation site   N-linked (GlcNAc...)   potential   394   394
glycosylation site   N-linked (GlcNAc...)   potential   400   400
glycosylation site   N-linked (GlcNAc...)   potential   405   405
glycosylation site   N-linked (GlcNAc...)   potential   442   442
glycosylation site   N-linked (GlcNAc...)   potential   457   457
glycosylation site   N-linked (GlcNAc...)   potential   611   611
glycosylation site   N-linked (GlcNAc...)   potential   616   616
glycosylation site   N-linked (GlcNAc...)   potential   625   625
glycosylation site   N-linked (GlcNAc...)   potential   637   637
glycosylation site   N-linked (GlcNAc...)   potential   674   674
site   Cleavage; by host furin   by similarity   510   511
site   In-frame UAG termination codon      760   760
short sequence motif   YXXL motif; contains endocytosis signal   by similarity   712   715
lipid moiety-binding region   S-palmitoyl cysteine; by host   by similarity   764   764
coiled-coil region      potential   542   592
coiled-coil region      potential   633   667

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MRVKGSGRNYQHLWRWGTMLLGILMICSAAE

Sequence

MRVKGSGRNYQHLWRWGTMLLGILMICSAAEQLWVTVYYGVPVWKEATTT
LFCASDAKAYDTEVHNIWATHACVPTDPNPQEVVLGNVTENFNMWKNNMV
EQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNLRNDTSTNATNTTSSNRG
KMEGGEMTNCSFNITTSIRSKVQKEYALFYKLDVVPIDNTSYTLINCNTS
VITQACPKVSFEPIPIHYCARWFAILNCNNKKFNGTGPCTNVSTVQCTHG
IRPVVSTHLLLNGSLAEEEVVLRSENFTDNAKTIIVQLKEAVEINCTRPN
NNTTRSIHIGPGRAFYATGDIIGDIRQAHCNISRAKWNNTLKQIVIKLRD
QFENKTIIFNRSSGGDPEIVMHSFNCGGEFFYCNSTQLFSSTWNGTEGSN
NTGGNDTITLPCRIKEIINMWQEVGKAMYAPPIKGQVKCSSNITGLLLTR
DGGNSKNGSKNENTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKA
KRRVVQREKRAVGTIGAMFLGFLGAAGSTMGATSMTLTVQARLLLSGIVQ
QQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSG
KLICTTTVPWNTSWSNKSLDKIWGNMTWMEWEREIDNYTSLIYTLIEESQ
NQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFT
VLSIVNRVRQGYSPLSFQTRLPSQRGPDRPEGIEEEGGERDRDRSGRLVD
GFLAIIWVDXRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLL
QYWSQELRNSAVSFVNATAIAVAEGTDRVIELLQRAFRAILHIPTRIRQG
LERALQ

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website