Signal Peptide Database

Signal Peptide Database - Mammalia

Entry Details

Source Database

UniProtKB/Swiss-Prot

UniProtKB/Swiss-Prot Accession Number

P27037 (Created: 1992-08-01 Updated: 2009-01-20)

UniProtKB/Swiss-Prot Entry Name

AVR2A_HUMAN

Protein Name

Activin receptor type-2A

Gene

ACVR2A

Organism Scientific

Homo sapiens

Organism Common

Human

Lineage

Eukaryota
  Metazoa
    Chordata
      Craniata
        Vertebrata
          Euteleostomi
            Mammalia
              Eutheria
                Euarchontoglires
                  Primates
                    Haplorrhini
                      Catarrhini
                        Hominidae
                          Homo

Protein Length [aa]

513

Protein Mass [Da]

57848

Features

TypeDescriptionStatusStartEnd
signal peptide      potential   1   19
chain   Activin receptor type-2A      20   513
disulfide bond      by similarity   30   60
disulfide bond      by similarity   50   78
disulfide bond      by similarity   85   104
disulfide bond      by similarity   91   103
disulfide bond      by similarity   105   110
transmembrane region      potential   136   161
topological domain   Extracellular   potential   20   135
topological domain   Cytoplasmic   potential   162   513
domain   Protein kinase      192   485
glycosylation site   N-linked (GlcNAc...)   potential   43   43
glycosylation site   N-linked (GlcNAc...)   potential   66   66
sequence variant         0   0
sequence variant   (in a gastric adenocarcinoma sample; somatic mutation)      0   0
active site   Proton acceptor   by similarity   322   322
binding site   ATP   by similarity   219   219
nucleotide phosphate-binding region   ATP   by similarity   198   206

SP Length

----+----1----+----2----+----3----+----4----+----5

Signal Peptide

MGAAAKLAFAVFLISCSSG

Sequence

MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPC
YGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEV
YFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLI
AGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKAR
GRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFI
GAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAG
KSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR
CTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAG
MAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTM
VTNVDFPPKESSL

Original

----+----1----+----2----+----3----+----4----+----5

Hydropathies

Signal Peptide Website